Geographical prevalence, risk factors and impact of hepatitis B and C after renal transplantation
Identifieur interne : 008308 ( Main/Exploration ); précédent : 008307; suivant : 008309Geographical prevalence, risk factors and impact of hepatitis B and C after renal transplantation
Auteurs : V. Kliem [Allemagne] ; U. Michel [Allemagne] ; M. Burg [Allemagne] ; A. Bock [Suisse] ; J. Chapman [Australie] ; B. Dussol [France] ; L. Fritsche [Allemagne] ; Y. Lebranchu [France] ; F. Oppenheimer [Espagne] ; E. Pohanka [Autriche] ; M. Salvadori [Italie] ; G. Tufveson [Suède]Source :
- Clinical nephrology [ 0301-0430 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
t. Background: Hepatitis B (HBV) and hepatitis C (HCV) virus infections are major risk factors affecting long-term morbidity and mortality after renal transplantation. Hepatitis prevalence is subject to geographical variations. Objective: To compare and analyze the geographical prevalence, risk factors and impact of HBV and HCV infection in multinational cohorts of renal transplant recipients. Methods: From 1989 - 2002, data on 12,856 kidney transplant recipients in 37 countries were collected within the prospective MOST (Multinational Observational Study in Transplantation). Subgroup analyses of hepatitis-related prevalence, risk factors and impact were conducted on patients whose HBV and HCV status was available at time of transplantation. Countries were substratified according to population prevalence of ≥ 5% HBV or ≥ 10% HCV. Results: The prevalence of HBV was 2.9%, of HCV 8.7% and of HBV together with HCV 0.4%. Risk factors for hepatitis infection in renal transplant recipients were long dialysis time, retransplantation and blood transfusions. At each study endpoint up to 5 years after transplantation, no significant differences in graft function were observed, although the 1-year acute rejection rate tended to be lower in HCV+ patients. At 5 years post-transplant, there were no differences between the subgroups and regions regarding infections, post-transplant diabetes mellitus or malignancies including PTLD. Conclusions: Overall, HCV infections are more prevalent than HBV. Despite large geographical differences in prevalence, HBV and HCV status did not appear to have a significant impact on renal graft function, infections, malignancies and post-transplant diabetes mellitus up to 5 years after renal transplantation throughout the MOST countries.
Affiliations:
- Allemagne, Australie, Autriche, Espagne, France, Italie, Suisse, Suède
- Berlin, Catalogne, Centre-Val de Loire, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région Centre, Vienne (Autriche)
- Barcelone, Berlin, Marseille, Sydney, Tours, Vienne (Autriche)
- Université de Sydney
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Bock</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Nephrology Division, Kantonsspital Aarau</s1><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Nephrology Division, Kantonsspital Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Transplant and Renal Research, Millennium Institute, Westmead Hospital, University of Sydney</s1><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Dussol, B" sort="Dussol, B" uniqKey="Dussol B" first="B." last="Dussol">B. Dussol</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Hôpital de la Conception</s1><s2>Marseille</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Fritsche, L" sort="Fritsche, L" uniqKey="Fritsche L" first="L." last="Fritsche">L. Fritsche</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Nephrology, University Hospital Campus Charité Mitte</s1><s2>Berlin</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lebranchu, Y" sort="Lebranchu, Y" uniqKey="Lebranchu Y" first="Y." last="Lebranchu">Y. Lebranchu</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU Tours, Hopital Bretonneau</s1><s2>Tours</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Oppenheimer, F" sort="Oppenheimer, F" uniqKey="Oppenheimer F" first="F." last="Oppenheimer">F. Oppenheimer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hopital Clinic de Barcelona, Unitat de Transplantament Renal</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pohanka, E" sort="Pohanka, E" uniqKey="Pohanka E" first="E." last="Pohanka">E. Pohanka</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Division of Nephrology and Dialysis, Internal Medicine III, Medizinische Universitat Wien</s1><s2>Vienna</s2><s3>AUT</s3><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Salvadori, M" sort="Salvadori, M" uniqKey="Salvadori M" first="M." last="Salvadori">M. Salvadori</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Renal Unit, Careggi University Hospital, Florence</s1><s2>Tuscany</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Tuscany</wicri:noRegion></affiliation></author><author><name sortKey="Tufveson, G" sort="Tufveson, G" uniqKey="Tufveson G" first="G." last="Tufveson">G. Tufveson</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Transplantation, Uppsala University Hospital</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0167648</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0167648 INIST</idno><idno type="RBID">Pascal:09-0167648</idno><idno type="wicri:Area/PascalFrancis/Corpus">002E83</idno><idno type="wicri:Area/PascalFrancis/Curation">003137</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002B04</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002B04</idno><idno type="wicri:doubleKey">0301-0430:2009:Kliem V:geographical:prevalence:risk</idno><idno type="wicri:Area/Main/Merge">008A73</idno><idno type="wicri:Area/Main/Curation">008308</idno><idno type="wicri:Area/Main/Exploration">008308</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Geographical prevalence, risk factors and impact of hepatitis B and C after renal transplantation</title><author><name sortKey="Kliem, V" sort="Kliem, V" uniqKey="Kliem V" first="V." last="Kliem">V. Kliem</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nephrological Center Niedersachsen Hann</s1><s2>Münden</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Münden</wicri:noRegion><wicri:noRegion>Nephrological Center Niedersachsen Hann</wicri:noRegion><wicri:noRegion>Nephrological Center Niedersachsen Hann</wicri:noRegion></affiliation></author><author><name sortKey="Michel, U" sort="Michel, U" uniqKey="Michel U" first="U." last="Michel">U. Michel</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Novartis Pharma GmbH Nürnberg</s1><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Novartis Pharma GmbH Nürnberg</wicri:noRegion><wicri:noRegion>Novartis Pharma GmbH Nürnberg</wicri:noRegion></affiliation></author><author><name sortKey="Burg, M" sort="Burg, M" uniqKey="Burg M" first="M." last="Burg">M. Burg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nephrological Center Niedersachsen Hann</s1><s2>Münden</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Münden</wicri:noRegion><wicri:noRegion>Nephrological Center Niedersachsen Hann</wicri:noRegion><wicri:noRegion>Nephrological Center Niedersachsen Hann</wicri:noRegion></affiliation></author><author><name sortKey="Bock, A" sort="Bock, A" uniqKey="Bock A" first="A." last="Bock">A. Bock</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Nephrology Division, Kantonsspital Aarau</s1><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Nephrology Division, Kantonsspital Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Transplant and Renal Research, Millennium Institute, Westmead Hospital, University of Sydney</s1><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Dussol, B" sort="Dussol, B" uniqKey="Dussol B" first="B." last="Dussol">B. Dussol</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Hôpital de la Conception</s1><s2>Marseille</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Fritsche, L" sort="Fritsche, L" uniqKey="Fritsche L" first="L." last="Fritsche">L. Fritsche</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Nephrology, University Hospital Campus Charité Mitte</s1><s2>Berlin</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lebranchu, Y" sort="Lebranchu, Y" uniqKey="Lebranchu Y" first="Y." last="Lebranchu">Y. Lebranchu</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU Tours, Hopital Bretonneau</s1><s2>Tours</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Oppenheimer, F" sort="Oppenheimer, F" uniqKey="Oppenheimer F" first="F." last="Oppenheimer">F. Oppenheimer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hopital Clinic de Barcelona, Unitat de Transplantament Renal</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pohanka, E" sort="Pohanka, E" uniqKey="Pohanka E" first="E." last="Pohanka">E. Pohanka</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Division of Nephrology and Dialysis, Internal Medicine III, Medizinische Universitat Wien</s1><s2>Vienna</s2><s3>AUT</s3><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Salvadori, M" sort="Salvadori, M" uniqKey="Salvadori M" first="M." last="Salvadori">M. Salvadori</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Renal Unit, Careggi University Hospital, Florence</s1><s2>Tuscany</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Tuscany</wicri:noRegion></affiliation></author><author><name sortKey="Tufveson, G" sort="Tufveson, G" uniqKey="Tufveson G" first="G." last="Tufveson">G. Tufveson</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Transplantation, Uppsala University Hospital</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical nephrology</title><title level="j" type="abbreviated">Clin. nephrol.</title><idno type="ISSN">0301-0430</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical nephrology</title><title level="j" type="abbreviated">Clin. nephrol.</title><idno type="ISSN">0301-0430</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Epidemiology</term><term>Kidney</term><term>Nephrology</term><term>Prevalence</term><term>Risk factor</term><term>Transplantation</term><term>Treatment</term><term>Urology</term><term>Viral hepatitis B</term><term>Viral hepatitis C</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prévalence</term><term>Epidémiologie</term><term>Facteur risque</term><term>Hépatite virale B</term><term>Hépatite virale C</term><term>Rein</term><term>Transplantation</term><term>Traitement</term><term>Néphrologie</term><term>Urologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">t. Background: Hepatitis B (HBV) and hepatitis C (HCV) virus infections are major risk factors affecting long-term morbidity and mortality after renal transplantation. Hepatitis prevalence is subject to geographical variations. Objective: To compare and analyze the geographical prevalence, risk factors and impact of HBV and HCV infection in multinational cohorts of renal transplant recipients. Methods: From 1989 - 2002, data on 12,856 kidney transplant recipients in 37 countries were collected within the prospective MOST (Multinational Observational Study in Transplantation). Subgroup analyses of hepatitis-related prevalence, risk factors and impact were conducted on patients whose HBV and HCV status was available at time of transplantation. Countries were substratified according to population prevalence of ≥ 5% HBV or ≥ 10% HCV. Results: The prevalence of HBV was 2.9%, of HCV 8.7% and of HBV together with HCV 0.4%. Risk factors for hepatitis infection in renal transplant recipients were long dialysis time, retransplantation and blood transfusions. At each study endpoint up to 5 years after transplantation, no significant differences in graft function were observed, although the 1-year acute rejection rate tended to be lower in HCV+ patients. At 5 years post-transplant, there were no differences between the subgroups and regions regarding infections, post-transplant diabetes mellitus or malignancies including PTLD. Conclusions: Overall, HCV infections are more prevalent than HBV. Despite large geographical differences in prevalence, HBV and HCV status did not appear to have a significant impact on renal graft function, infections, malignancies and post-transplant diabetes mellitus up to 5 years after renal transplantation throughout the MOST countries.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li><li>Suisse</li><li>Suède</li></country><region><li>Berlin</li><li>Catalogne</li><li>Centre-Val de Loire</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Région Centre</li><li>Vienne (Autriche)</li></region><settlement><li>Barcelone</li><li>Berlin</li><li>Marseille</li><li>Sydney</li><li>Tours</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Kliem, V" sort="Kliem, V" uniqKey="Kliem V" first="V." last="Kliem">V. Kliem</name></noRegion><name sortKey="Burg, M" sort="Burg, M" uniqKey="Burg M" first="M." last="Burg">M. Burg</name><name sortKey="Fritsche, L" sort="Fritsche, L" uniqKey="Fritsche L" first="L." last="Fritsche">L. Fritsche</name><name sortKey="Michel, U" sort="Michel, U" uniqKey="Michel U" first="U." last="Michel">U. Michel</name></country><country name="Suisse"><noRegion><name sortKey="Bock, A" sort="Bock, A" uniqKey="Bock A" first="A." last="Bock">A. Bock</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name></region></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Dussol, B" sort="Dussol, B" uniqKey="Dussol B" first="B." last="Dussol">B. Dussol</name></region><name sortKey="Lebranchu, Y" sort="Lebranchu, Y" uniqKey="Lebranchu Y" first="Y." last="Lebranchu">Y. Lebranchu</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Oppenheimer, F" sort="Oppenheimer, F" uniqKey="Oppenheimer F" first="F." last="Oppenheimer">F. Oppenheimer</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pohanka, E" sort="Pohanka, E" uniqKey="Pohanka E" first="E." last="Pohanka">E. Pohanka</name></region></country><country name="Italie"><noRegion><name sortKey="Salvadori, M" sort="Salvadori, M" uniqKey="Salvadori M" first="M." last="Salvadori">M. Salvadori</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Tufveson, G" sort="Tufveson, G" uniqKey="Tufveson G" first="G." last="Tufveson">G. Tufveson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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